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In this article, we introduce the packagebinsreg, which implements the binscatter methods developed by Cattaneo et al. (2024a, arXiv:2407.15276 [stat.EM]; 2024b,American Economic Review114: 1488–1514). The package comprises seven commands:binsreg, binslogit, binsprobit, binsqreg, binstest binspwc, andbinsregselect. The first four commands implement binscatter plotting, point estimation, and uncertainty quantification (confidence intervals and confidence bands) for least-squares linear binscatter regression (binsreg) and for nonlinear binscatter regression (binslogitfor logit regression,binsprobitfor. probit regression, andbinsqregfor quantile regression). The next two commands focus on pointwise and uniform inference:binstestimplements hypothesis testing procedures for parametric specifications and for nonparametric shape restrictions of the unknown regression function, whilebinspwcimplements multigroup pairwise statistical comparisons. The last command,binsregselect, implements. data-driven number-of-bins selectors. The commands offer binned scatterplots and allow for covariate adjustment, weighting, clustering, and multisample analysis, which is useful when studying treatment-effect heterogeneity in randomizec and observational studies, among many other features. 

Binscatter is a popular method for visualizing bivariate relationships and conducting informal specification testing. We study the properties of this method formally and develop enhanced visualization and econometric binscatter tools. These include estimating conditional means with optimal binning and quantifying uncertainty. We also highlight a methodological problem related to covariate adjustment that can yield incorrect conclusions. We revisit two applications using our methodology and find substantially different results relative to those obtained using prior informal binscatter methods. General purpose software in Python, R, and Stata is provided. Our technical work is of independent interest for the nonparametric partition-based estimation literature. (JEL C13, C14, C18, C51, O31, R32) 

We presented a novel radiomics approach using multimodality MRI to predict the expression of an oncogene (O6-Methylguanine-DNA methyltransferase, MGMT) and overall survival (OS) of glioblastoma (GBM) patients. Specifically, we employed an EffNetV2-T, which was down scaled and modified from EfficientNetV2, as the feature extractor. Besides, we used evidential layers based to control the distribution of prediction outputs. The evidential layers help to classify the high-dimensional radiomics features to predict the methylation status of MGMT and OS. Tests showed that our model achieved an accuracy of 0.844, making it possible to use as a clinic-enabling technique in the diagnosing and management of GBM. Comparison results indicated that our method performed better than existing work.